Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons
Identifieur interne : 005741 ( Main/Exploration ); précédent : 005740; suivant : 005742Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons
Auteurs : Dipanjan Pan [États-Unis] ; Manojit Pramanik [États-Unis] ; Angana Senpan [États-Unis] ; Soumojit Ghosh [États-Unis] ; Samuel A. Wickline [États-Unis] ; Lihong V. Wang [États-Unis] ; Gregory M. Lanza [États-Unis]Source :
- Biomaterials [ 0142-9612 ] ; 2010.
Abstract
Detection of sentinel lymph node (SLN) using photoacoustic imaging is an emerging technique for noninvasive axillary staging of breast cancer. Due to the absence of intrinsic contrast inside the lymph nodes, exogenous contrast agents are used for photoacoustic detection. In this work, we have demonstrated near infrared detection of SLN with gold nanobeacons (GNB) providing the photoacoustic contrast in a rodent model. We found that size dictates the
Url:
DOI: 10.1016/j.biomaterials.2010.01.136
PubMed: 20172607
PubMed Central: 2874457
Affiliations:
- États-Unis
- Missouri (État)
- Saint-Louis (Missouri)
- Université Washington de Saint-Louis, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P2">Detection of sentinel lymph node (SLN) using photoacoustic imaging is an emerging technique for noninvasive axillary staging of breast cancer. Due to the absence of intrinsic contrast inside the lymph nodes, exogenous contrast agents are used for photoacoustic detection. In this work, we have demonstrated near infrared detection of SLN with gold nanobeacons (GNB) providing the photoacoustic contrast in a rodent model. We found that size dictates the <italic>in vivo</italic>
characteristics of these nanoparticles in SLN imaging. Larger nanobeacons with high pay loads of gold were not as efficient as smaller size nanobeacons with lower pay loads for this purpose. Colloidal GNBs were designed as a nanomedicine platform with “soft” nature that is amenable to bio-elimination, an essential feature for <italic>in vivo</italic>
efficacy and safety. The GNBs were synthesized as lipid- or polymer-encapsulated colloidal particles incorporating tiny gold nanoparticles (2–4 nm) in three tunable sizes (90 nm, 150 nm and 290 nm). Smaller GNBs were noted trafficking through the lymphatic system and accumulating more efficiently in the lymph nodes in comparison to the bigger nanoagents. At 20 min, the GNBs reached the SLN and were no longer observed within the draining lymphatic vessel. Within one hour post injection, the contrast ratio of the lymphnodes with the surrounding blood vessels was 9:1. These findings were also supported by analytical measurements of the <italic>ex vivo</italic>
tissue samples. Results indicate that cumulative nanoparticle deposition in lymph nodes is size dependent and that high payloads of gold, although offering greater contrast <italic>in vitro</italic>
, may yield nanoagents with poor intradermal migration and lymphatic transport characteristics.</p>
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